GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs11171846 | 1 | rs11171846 | chr12:56828056 | TIMELESS | chr12:56810157-56843200:- | -0.22 | -5.36 | 1.03E-7 | Immune reponse to smallpox (secreted IFN-alpha) |
| BRCA | cis | rs703842 | 1 | rs11172333 | chr12:58170335 | B4GALNT1 | chr12:58019551-58026985:- | 0.13 | 3.72 | 0.000209 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs11172333 | chr12:58170335 | FAM119B | chr12:58166383-58176323:+ | 0.43 | 10.65 | 3.16E-25 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs11172333 | chr12:58170335 | TSFM | chr12:58176536-58191367:+ | -0.35 | -10.15 | 3.65E-23 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs11172333 | chr12:58170335 | XRCC6BP1 | chr12:58335445-58351051:+ | -0.18 | -5.08 | 4.42E-7 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs11172335 | chr12:58175201 | B4GALNT1 | chr12:58019551-58026985:- | 0.12 | 3.51 | 0.00047 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs11172335 | chr12:58175201 | FAM119B | chr12:58166383-58176323:+ | 0.43 | 10.52 | 1.07E-24 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs11172335 | chr12:58175201 | TSFM | chr12:58176536-58191367:+ | -0.36 | -10.5 | 1.35E-24 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs11172335 | chr12:58175201 | XRCC6BP1 | chr12:58335445-58351051:+ | -0.19 | -5.11 | 3.78E-7 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs11172342 | chr12:58187758 | B4GALNT1 | chr12:58019551-58026985:- | 0.12 | 3.49 | 0.000504 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs11172342 | chr12:58187758 | FAM119B | chr12:58166383-58176323:+ | 0.43 | 10.52 | 1.09E-24 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs11172342 | chr12:58187758 | TSFM | chr12:58176536-58191367:+ | -0.36 | -10.51 | 1.19E-24 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs11172342 | chr12:58187758 | XRCC6BP1 | chr12:58335445-58351051:+ | -0.19 | -5.1 | 3.94E-7 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs11172343 | chr12:58188157 | B4GALNT1 | chr12:58019551-58026985:- | 0.12 | 3.49 | 0.000504 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs11172343 | chr12:58188157 | FAM119B | chr12:58166383-58176323:+ | 0.43 | 10.52 | 1.09E-24 | Multiple sclerosis |